CHF (Exertional or paroxysmal nocturnal dyspnea and has responded to digitalis, diuretics, or afterload reducing agents).
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Peripheral vascular disease (Intermittent claudication or past bypass for chronic arterial insufficiency, history of gangrene or acute arterial insufficiency, or untreated thoracic or abdominal aneurysm (≥6 cm))
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CVA or TIA (History of a cerebrovascular accident with minor or no residua and transient ischemic attacks)
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Dementia (Chronic cognitive deficit)
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Connective tissue disease
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Peptic ulcer disease (Any history of treatment for ulcer disease or history of ulcer bleeding)
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Liver disease (Severe = cirrhosis and portal hypertension with variceal bleeding history, moderate = cirrhosis and portal hypertension but no variceal bleeding history, mild = chronic hepatitis (or cirrhosis without portal hypertension))
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Moderate to severe CKD (Severe = on dialysis, status post kidney transplant, uremia, moderate = creatinine >3 mg/dL (0.27 mmol/L))
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