DIPSS Prognosis in Myelofibrosi


DIPSS Prognosis in Myelofibrosi
Age, years
White blood cell count, x10⁹/dL
Hemoglobin, g/dL
Peripheral blood blasts
Constitutional symptoms

Greetings, curious minds! Ever found yourself mulling over the Dynamic International Prognostic Scoring System (DIPSS) and its application in Myelofibrosis prognosis? Strap in, because we’re about to embark on an enlightening journey! Now, don’t let the humor fool you, this is serious stuff.

The DIPSS scoring system is calculated as follows:

score = 0
if age > 65:
    score += 1
if hemoglobin < 10 g/dL:
    score += 2
if leukocytes > 25 x 10^9/L:
    score += 1
if circulating blast cells >= 1%:
    score += 1
if constitutional symptoms are present:
    score += 1

DIPSS Score Categories

Score Category Survival (Years)
0 Low > 15.4
1-2 Int-1 6.5
3-4 Int-2 2.9
5-6 High 1.3

Examples of DIPSS Calculations

Age Hemoglobin Leukocytes Circulating Blast Cells Symptoms Score Category
68 9.5 27 1.1 Yes 5 High
64 11 24 0.9 No 0 Low

Evolution of DIPSS Prognosis

Year Changes
2010 Initial introduction
2012 Update to include three additional parameters

Limitations of DIPSS

  1. Inaccuracy: The DIPSS may not provide an accurate prognosis for all patients.
  2. Individual Variation: The DIPSS does not account for individual patient variations.

Alternative Methods

Method Pros Cons


  1. What is DIPSS?: DIPSS is a prognostic scoring system used in myelofibrosis.
  2. How is DIPSS calculated?: The DIPSS score is calculated based on several factors, including age, hemoglobin count, leukocytes count, circulating blast cells and presence of symptoms.
  3. What do DIPSS scores mean?: The DIPSS score is used to categorize patients into different risk categories: Low, Int-1, Int-2, and High.
  4. How accurate is DIPSS?: While DIPSS is a useful tool, it may not provide accurate prognosis for all patients due to individual variations.
  5. What are the limitations of DIPSS?: The main limitations of DIPSS include its potential inaccuracy and inability to account for individual patient variations.
  6. Are there alternative methods to DIPSS?: Yes, there are alternative methods to DIPSS. However, each method has its own pros and cons.
  7. What are the alternative methods to DIPSS?: The alternative methods to DIPSS are currently not specified.
  8. How has DIPSS evolved over time?: The DIPSS was initially introduced in 2010 and was updated in 2012 to include three additional parameters.
  9. Where can I find more information on DIPSS?: You can find more information on DIPSS on reliable government and educational platforms such as the National Institutes of Health.
  10. Can DIPSS predict survival?: Yes, the DIPSS score can provide an estimate of survival in years depending on the risk category.


  1. National Institutes of Health: Comprehensive information on DIPSS.