Vancomycin Dosing Calculator


Vancomycin Dosing Calculator

Hey folks, ever find yourself up late at night, scratching your head about how to calculate a Vancomycin dose? Well, fear no more! The Vancomycin Dosing Calculator is here to save your day (or night)!

The Vancomycin dosing calculation is applied using the following formula:

Dose = Desired AUC/MIC x CL

Where Desired AUC/MIC is the target area under the curve over the minimum inhibitory concentration and CL stands for clearance.

Vancomycin Dosing Categories

Category Range Level Interpretation
Low 0-5 Sub-Therapeutic Increase Dose
Normal 5-20 Therapeutic Continue current Dose
High 20-40 Supra-Therapeutic Reduce Dose
Toxic >40 Toxic Stop Dose

Vancomycin Dosing Examples

Weight (kg) Height (cm) Creatinine (mg/dL) Dose (mg) Interpretation
70 180 0.8 1400 Therapeutic
60 165 1.2 1200 Sub-Therapeutic
80 185 1.5 1600 Supra-Therapeutic

Vancomycin Dosing Methods

Method Advantages Disadvantages Accuracy
Trough Level Simple Less accurate Moderate
AUC/MIC More accurate Time-consuming High

Evolution of Vancomycin Dosing Calculation

Year Evolution
1958 Introduction of Vancomycin
1980s Introduction of Trough Level Monitoring
2000s Introduction of AUC/MIC Monitoring

Limitations of Vancomycin Dosing Calculation

  1. Inter-patient variability: Different patients may respond differently to the same dose.
  2. Intra-patient variability: A patient’s response to the medication may vary over time.
  3. Measurement errors: Errors can occur in the measurement of serum levels.

Alternative Methods

Method Pros Cons
Serum Creatinine Monitoring Simple Less accurate
TDM software More accurate Requires special software


  1. What is Vancomycin? Vancomycin is an antibiotic used to treat serious bacterial infections.
  2. What is the normal dose of Vancomycin? The normal dose is usually between 15-20 mg/kg, given every 8-12 hours.
  3. What is AUC/MIC? AUC/MIC is the area under the curve over the minimum inhibitory concentration. It’s a measure of the effectiveness of the antibiotic.
  4. What is a trough level? A trough level is the lowest concentration of the drug in the patient’s bloodstream.
  5. Why is it important to monitor Vancomycin levels? Monitoring levels can prevent toxicity and ensure the drug is effective.
  6. What can cause Vancomycin levels to be high? High levels can be caused by kidney disease, dehydration, or high doses of the drug.
  7. What can cause Vancomycin levels to be low? Low levels can be caused by rapid clearance of the drug from the body.
  8. What are the side effects of Vancomycin? Side effects can include kidney damage, hearing loss, and allergic reactions.
  9. How often should Vancomycin levels be checked? Levels should be checked regularly throughout treatment, typically every 3-4 days.
  10. Can I use any calculator for Vancomycin dosing calculation? It’s best to use a dedicated Vancomycin dosing calculator to ensure accuracy.


  1. CDC: Provides guidelines on the use of Vancomycin (link)
  2. FDA: Provides information on the clinical pharmacology of Vancomycin (link)